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Docetaxel (as generic or subservient to the trade eminence Taxotere) is a clinically well-established anti-mitotic chemotherapy medication (medication which interferes with cell allotment). It is worn large for the treatment of mamma, ovarian, prostate, and non-small chamber lung cancer.[1 – [2 – [3 – Docetaxel has an FDA approved claim as a service to treatment of patients who arrange locally advanced, or metastatic mamma or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to impede cancer progression or relapsed[4 – and a European approval instead of work in hormone-refractory prostate cancer.[5 –
According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks as a rule as surplus a ten recur dispatch, docetaxel is considered as or more effective than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 – However the effectiveness of docetaxel versus paclitaxel and other taxanes is quiescent controversial. Diverse more current articles have build “no demonstration that regimens containing docetaxel yield greater benefits than those including paclitaxel.”[6 – Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution schedule utilized to be and is until now considered operative but new studies are indicating a weekly outline effect be better. A 2010 article in Accepted Clinical Pharmacology states, “weekly application has emerged as the optimal schedule.” Docetaxel is marketed worldwide subordinate to the high regard Taxotere on Sanofi-Aventis.[7 – Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.[citation
Nature
Docetaxel is of the chemotherapy opiate savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.[2 – Due to paucity of paclitaxel, international research was carried peripheral exhausted unsurpassed to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and readily available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string as an alternative of the benzyl amide in paclitaxel. The carbon 10 practical team mutation causes docetaxel to be more bath-water soluble than paclitaxel.[2 –
Formulations and compositions
Docetaxel is a snowy right and is the strenuous ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 – [8 – The answer is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 – 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a single portion Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose recompense administration.[8 – 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to pay a solution of 10 mg/mL and the required dose is haggard from this solution. Vials be suffering with an overfill to indemnify as a replacement for fluid set-back during preparation, foaming, adhesion to vial walls and the uninteresting volume. 20 mg vials may be stored looking for 24 months in this world 25 °C away from insight and 80 mg vials since 26 months in the same conditions.[8 –
Recently Sanofi has got approval payment one-vial formulation.[citation needed – With this one-vial formulation, the preparation of the infusion infusion is simplified by eliminating the fundamental dilution step. The two-vial and one-vial formulations in the at any rate drug theme, docetaxel trihydrate, and the uniform excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the despite the fact drug theme in the same concentration as the already approved two-vial formulation. The in spite of grade, quality, and volume of polysorbate 80 are put on show in the infusion revelation of both formulations. The solely remainder between these two formulations is the quantity of ethanol.
From http://www.fmyykj.com – suzhou pharmaceutical technology co.,ltd.

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Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT).

Both hormones are stored in the thyroid colloid as thyroglobulin.

Thyroid hormone preparations belong to two categories: (1) natural hormonal preparations derived from animal thyroid, and (2) synthetic preparations. Natural preparations include desiccated thyroid and thyroglobulin. Desiccated thyroid is derived from domesticated animals that are used for food by man (either beef or hog thyroid), and thyroglobulin is derived from thyroid glands of the hog. The United States Pharmacopeia (USP) has standardized the total iodine content of natural preparations. Thyroid USP contains not less than (NLT) 0.17 percent and not more than (NMT) 0.23 percent iodine, and thyroglobulin contains not less than (NLT) 0.7 percent of organically bound iodine. Iodine content is only an indirect indicator of true hormonal biologic activity. Cytomel (liothyronine sodium) (liothyronine sodium) Tablets contain liothyronine (L-triiodothyronine or LT3), a synthetic form of a natural thyroid hormone, and is available as the sodium salt.
From http://www.tcsindustry.com – TCS INDUSTRY LTD

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